Research Collaborations
The EPIC4 study is a Canadian study which aims to find out if HIV viral remission is possible following the early initiation of cART in children perinatally infected with HIV at the time of birth.
L'Étude EPIC4 est une initiative de chercheurs canadiens qui vise à répondre à la question suivante: La rémission virale de l’infection par le VIH est-elle possible en traitant tôt par thérapie antirétrovirale combinée les enfants infectés par le VIH à la naissance.
L'Étude EPIC4 est une initiative de chercheurs canadiens qui vise à répondre à la question suivante: La rémission virale de l’infection par le VIH est-elle possible en traitant tôt par thérapie antirétrovirale combinée les enfants infectés par le VIH à la naissance.
References - Références
Choudhury B*, Brown J, Ransy DG, Brophy J, Kakkar F, Bitnun A, Samson L, Read S, Soudyns H, Vaudry W, Houston S, Hawkes MT, and the EPIC4 Study Team. Endothelial activation is associated with microbial translocation, systemic inflammation, and treatment regimen in children living with vertically acquired HIV-1 infection. HIV Med. 2021 Apr;22(4):273-282. doi: 10.1111/hiv.13012. Epub 2020 Nov 5
Kakkar F, Lee T, Hawkes MT, Brophy J, Samson L, Singer J, Dieumegard H, Sauvé L, Alimenti A, Vaudry W, Seigel S, Tan B, Karatzios C, Lamarre V, Read S, Soudeyns H, Bitnun A; EPIC4 Study Group. Challenges to achieving and maintaining viral suppression among Canadian children living with perinatal HIV infection in the EPIC4 cohort. AIDS. 2020 Apr 1;34(5):687-697
Bitnun A, Ransy DG, Brophy J, Kakkar F, Hawkes M, Samson L, Annabi B, Pagliuzza A, Morand JA, Sauve L, Chomont N, Lavoie S, Kim J, Sandstrom P, Wender PA, Lee T, Singer J, Read SE, Soudeyns H; Early Pediatric Initiation Canada Child Cure Cohort (EPIC4) Research Group. Clinical Correlates of Human Immunodeficiency Virus-1 (HIV-1) DNA and Inducible HIV-1 RNA Reservoirs in Peripheral Blood in Children With Perinatally Acquired HIV-1 Infection With Sustained Virologic Suppression for at Least 5 Years. Clin Infect Dis. 2020 Feb 14; 70(5): 859-866.
Gulhati V, Soo J, Ransy DG, Brophy J, Kakkar F, Bitnun A, Samson L, Read S, Soudeyns H, Hawkes MT; for EPIC4 Study Group. Brief Report: Higher Levels of Angiopoietin-1 Are Associated With Early and Sustained Viral Suppression in Children Living With Vertically Acquired HIV. J Acquir Immune Defic Syndr. 2019 Apr 15; 80(5): 590-595.
Kakkar F, Lee T, Hawkes MT, Brophy J, Lindy S, Singer J, Dieumegard H, Sauve L, Alimenti A, Vaudry W, Seigel S, Tan B, Karatzios C, Lamarre V, Read S, Soudeyns H, Bitnun A; EPIC4 Study Group. Challenges to achieving and maintaining viral suppression among children living with HIV. AIDS. 2020 Apr 1; 34(5): 687-697.
Kakkar F, Lee T, Hawkes MT, Brophy J, Samson L, Singer J, Dieumegard H, Sauvé L, Alimenti A, Vaudry W, Seigel S, Tan B, Karatzios C, Lamarre V, Read S, Soudeyns H, Bitnun A; EPIC4 Study Group. Challenges to achieving and maintaining viral suppression among Canadian children living with perinatal HIV infection in the EPIC4 cohort. AIDS. 2020 Apr 1;34(5):687-697
Bitnun A, Ransy DG, Brophy J, Kakkar F, Hawkes M, Samson L, Annabi B, Pagliuzza A, Morand JA, Sauve L, Chomont N, Lavoie S, Kim J, Sandstrom P, Wender PA, Lee T, Singer J, Read SE, Soudeyns H; Early Pediatric Initiation Canada Child Cure Cohort (EPIC4) Research Group. Clinical Correlates of Human Immunodeficiency Virus-1 (HIV-1) DNA and Inducible HIV-1 RNA Reservoirs in Peripheral Blood in Children With Perinatally Acquired HIV-1 Infection With Sustained Virologic Suppression for at Least 5 Years. Clin Infect Dis. 2020 Feb 14; 70(5): 859-866.
Gulhati V, Soo J, Ransy DG, Brophy J, Kakkar F, Bitnun A, Samson L, Read S, Soudeyns H, Hawkes MT; for EPIC4 Study Group. Brief Report: Higher Levels of Angiopoietin-1 Are Associated With Early and Sustained Viral Suppression in Children Living With Vertically Acquired HIV. J Acquir Immune Defic Syndr. 2019 Apr 15; 80(5): 590-595.
Kakkar F, Lee T, Hawkes MT, Brophy J, Lindy S, Singer J, Dieumegard H, Sauve L, Alimenti A, Vaudry W, Seigel S, Tan B, Karatzios C, Lamarre V, Read S, Soudeyns H, Bitnun A; EPIC4 Study Group. Challenges to achieving and maintaining viral suppression among children living with HIV. AIDS. 2020 Apr 1; 34(5): 687-697.
CARMA-2-CORE: HIV medications and cellular aging
CARMA-2-CORE is studying the effects of HIV and anti-HIV medications on cellular aging among children and adults living with, or exposed to HIV. As people with HIV are living longer, there is increasing evidence that HIV may cause a type of “early aging”.
CARMA-2-CORE is trying to better understand the impact of HIV and the anti-HIV medications on aging by looking at two markers of cellular aging: the length of DNA at the ends of chromosomes (“telomeres”) and the energy producing parts of the cell (“mitochondrial DNA”). Find out more. >>
CARMA-2-CORE is trying to better understand the impact of HIV and the anti-HIV medications on aging by looking at two markers of cellular aging: the length of DNA at the ends of chromosomes (“telomeres”) and the energy producing parts of the cell (“mitochondrial DNA”). Find out more. >>
CARMA-1-Preg : Factors related to pre-term deliveries
CARMA-1-PREG is investigating factors related to pre-term deliveries among HIV positive women. Research has shown that HIV+ pregnant women are 2x more likely to deliver their babies early (more than 3 weeks before their due dates), compared to women without HIV. The purpose of CARMA-1-PREG is to study the effects of particular anti-HIV medications on pregnant women and on their infants by examining two markers of cell function: the length of DNA at the ends of chromosomes (“telomeres”) and the energy producing parts of the cell (“mitochondrial DNA”). CARMA-1-PREG also investigates how HIV, anti-HIV medications and other factors (e.g. the bacterial environment of a pregnant woman’s vagina) may affect early delivery. Find out more. >>
CARMA-7: Effects of TDF Exposure In-utero
Anti-HIV medication has reduced the risk of HIV transmission from mother to child from 25% to less than 1%. However, the effects of some of these anti-HIV medications on the developing fetus have not yet been thoroughly studied. One medication in particular, called “Tenofovir”, can cause some bone and kidney problems for HIV+ adults when taken for a long time, especially with existing bone and kidney diseases. The purpose of CARMA 7 is to investigate how fetal exposure to Tenofovir may affect the bone and kidney health of infants who are born to HIV+ women. Find out more. >>
CARMA References - Références CARMA
Anthony Y.Y. Hsieh, Elana Kimmel, Neora Pick, Laura Sauvé, Jason Brophy, Fatima Kakkar, Ari Bitnun, Melanie C.M. Murray, Hélène C.F. Côté. Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time. Aging (Albany NY) 2020 Aug 15; 12(15): 15196–15221. Published online 2020 Jul 23. doi: 10.18632/aging.103703
Saberi S & al. Robust Tobacco Smoking Self-Report in two Cohorts of Vulnerable Pregnant Women and Adults. bioRxiv preprint doi: https://doi.org/10.1101/2020.09.11.293902. 12 Sept. 2020.
Ajaykumar A, Zhu M, Kakkar F, Brophy J, Bitnun A, Alimenti A, Soudeyns H, Saberi S, Albert AYK, Money DM, CÔtÉ HCF; CIHR Team in Cellular Aging and HIV Comorbidities in Women and Children (CARMA). Blood mitochondrial DNA levelsremain elevated from birth to early life in children HIV-exposed uninfected exposed to combination antiretroviral therapy in utero. J Infect Dis. 2020 Jul 8: jiaa410.
Ziada AS, Lu MY, Ignas-Menzies J, Paintsil E, Li M, Ogbuagu O, Saberi S, Hsieh AYY, Sattha B, Harrigan PR, Kalloger S, Côté HCF; CIHR team grant on cellular aging, HIV comorbidities in women, children (CARMA). Mitochondrial DNA somatic mutation burden and heteroplasmy are associated with chronological age, smoking, and HIV infection. Aging Cell. 2019 Dec; 18(6): e13018.
Côté HC, Soudeyns H, Thorne A, Alimenti A, Lamarre V, Maan EJ, Sattha B, Singer J, Lapointe N, Money DM, Forbes J; CIHR Emerging Team in HIV therapy, aging (CARMA), Wong J, Bitnun A, Samson L, Brophy J, Burdge D, Pick N, van Schalkwyk J, Montaner J, Harris M, Janssen P. Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia. PLoS One. 2012; 7(7): e39266.
Saberi S & al. Robust Tobacco Smoking Self-Report in two Cohorts of Vulnerable Pregnant Women and Adults. bioRxiv preprint doi: https://doi.org/10.1101/2020.09.11.293902. 12 Sept. 2020.
Ajaykumar A, Zhu M, Kakkar F, Brophy J, Bitnun A, Alimenti A, Soudeyns H, Saberi S, Albert AYK, Money DM, CÔtÉ HCF; CIHR Team in Cellular Aging and HIV Comorbidities in Women and Children (CARMA). Blood mitochondrial DNA levelsremain elevated from birth to early life in children HIV-exposed uninfected exposed to combination antiretroviral therapy in utero. J Infect Dis. 2020 Jul 8: jiaa410.
Ziada AS, Lu MY, Ignas-Menzies J, Paintsil E, Li M, Ogbuagu O, Saberi S, Hsieh AYY, Sattha B, Harrigan PR, Kalloger S, Côté HCF; CIHR team grant on cellular aging, HIV comorbidities in women, children (CARMA). Mitochondrial DNA somatic mutation burden and heteroplasmy are associated with chronological age, smoking, and HIV infection. Aging Cell. 2019 Dec; 18(6): e13018.
Côté HC, Soudeyns H, Thorne A, Alimenti A, Lamarre V, Maan EJ, Sattha B, Singer J, Lapointe N, Money DM, Forbes J; CIHR Emerging Team in HIV therapy, aging (CARMA), Wong J, Bitnun A, Samson L, Brophy J, Burdge D, Pick N, van Schalkwyk J, Montaner J, Harris M, Janssen P. Leukocyte telomere length in HIV-infected and HIV-exposed uninfected children: shorter telomeres with uncontrolled HIV viremia. PLoS One. 2012; 7(7): e39266.
CTN 236: HPV Vaccine in HIV Positive Girls and Women
The purpose of this study is to investigate the safety and immunogenicity of the human papillomavirus (HPV) vaccine in girls and women age 9 years and older who are infected with HIV. Find out more. >>
References - Références
Budd MA, Calli K, Samson L, Bowes J, Hsieh AYY, Forbes JC, Bitnun A, Singer J, Kakkar F, Alimenti A, Maan EJ, Lewis MES, Gentile C, Côté HCF, Brophy JC. Blood Mitochondrial DNA Content in HIV-Exposed Uninfected Children with Autism Spectrum Disorder.
Viruses. 2018 Feb 11; 10(2): 77.
Kennedy VL, Mellor KL, Brophy J, Bitnun A, Alimenti A, Kakkar F, Logie CH, Webster K, Proulx-Boucher K, Ding E, Jabbari S, Kaida A, de Pokomandy A, Loutfy M; CHIWOS Research Team. Transition from Pediatric to Adult HIV Care for Young Women Living with HIV. J Int Assoc Provid AIDS Care. 2020 Jan-Dec; 19: 2325958220903574.
Transition from Pediatric to Adult HIV Care for Young Women Living with HIV. J Int Assoc Provid AIDS Care. 2020 Jan-Dec;19:2325958220903574. doi:10.1177/2325958220903574. PMID: 32207355
McClymont E, Ogilvie G, Albert A, Johnston A, Raboud J, Walmsley S, Lipsky N, Loutfy M, Trottier S, Smaill F, Yudin MH, Klein MB, Harris M, Wobeser W, Bitnun A, Kakkar F, Samson L, Brophy J, Karatzios C, Money D; CTN 236 HPV in HIV Study Team. Impact of quadrivalent HPV vaccine dose spacing on immunologic response in women living with HIV. Vaccine. 2020 Mar 30; 38(15): 3073-3078.
Hsieh AYY, Kimmel E, Pick N, Sauvé L, Brophy J, Kakkar F, Bitnun A, Murray MCM, Côté HCF. Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time. Aging (Albany NY). 2020 Jul 23; 12. Online ahead of print. PMID: 32703912.
Viruses. 2018 Feb 11; 10(2): 77.
Kennedy VL, Mellor KL, Brophy J, Bitnun A, Alimenti A, Kakkar F, Logie CH, Webster K, Proulx-Boucher K, Ding E, Jabbari S, Kaida A, de Pokomandy A, Loutfy M; CHIWOS Research Team. Transition from Pediatric to Adult HIV Care for Young Women Living with HIV. J Int Assoc Provid AIDS Care. 2020 Jan-Dec; 19: 2325958220903574.
Transition from Pediatric to Adult HIV Care for Young Women Living with HIV. J Int Assoc Provid AIDS Care. 2020 Jan-Dec;19:2325958220903574. doi:10.1177/2325958220903574. PMID: 32207355
McClymont E, Ogilvie G, Albert A, Johnston A, Raboud J, Walmsley S, Lipsky N, Loutfy M, Trottier S, Smaill F, Yudin MH, Klein MB, Harris M, Wobeser W, Bitnun A, Kakkar F, Samson L, Brophy J, Karatzios C, Money D; CTN 236 HPV in HIV Study Team. Impact of quadrivalent HPV vaccine dose spacing on immunologic response in women living with HIV. Vaccine. 2020 Mar 30; 38(15): 3073-3078.
Hsieh AYY, Kimmel E, Pick N, Sauvé L, Brophy J, Kakkar F, Bitnun A, Murray MCM, Côté HCF. Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time. Aging (Albany NY). 2020 Jul 23; 12. Online ahead of print. PMID: 32703912.
CPARG investigators are also supported by the CTN (CIHR Canadian HIV Trials Network (Engl.) >>
Les chercheurs de CPARG profitent aussi de l'appui du Réseau canadien pour les essais VIH -- (Réseau) des IRSC (Fr.) >>
Les chercheurs de CPARG profitent aussi de l'appui du Réseau canadien pour les essais VIH -- (Réseau) des IRSC (Fr.) >>